BreathBiomicsTM Technology

    Unlocking the full potential of human breath as a non-invasive source for disease diagnosis requires technologies that are both sensitive and robust. At Zeteo Tech, we’ve answered this call by developing a sampling system that excels where existing methods fall short. Our innovative approach captures biological molecules in human breath with unparalleled accuracy and reliability, delivering a powerful tool to complement traditional diagnostic methods. Whether for clinical research or everyday use, our sampling system is poised to revolutionize the way we detect and manage respiratory diseases.

     

    Zeteo Tech has renovated the capturing mechanism and developed a sampling system, BreathBiomicsTM, for the comprehensive collection of biomolecules in human breath. 

     

    Highlights of BreathBiomicsTM

    • Comprehensive capture of biomolecules
    • Easy to use
    • Small footprint
    • Suitable for use in clinical and point-of-care settings
    • Compatible with conventional analytical methods

    A novel mechanism to capture biomolecules in human breath

    BreathBiomicsTM sampling system offers a novel capture mechanism through advanced surface chemistry, providing a comprehensive and efficient collection of non-volatile organic compounds present in human breath. Our system is composed of chemically modified functional groups that display high affinity for a diverse range of biomolecules, including lipids, metabolites, and proteins, allowing for a thorough and accurate assessment of respiratory health. The molecular interactions utilized in our capture mechanism enable the collection of biomolecules contained within submicron particles, overcoming a critical limitation of existing collection technologies. Furthermore, our system’s functional groups can be tailored for targeted collection, such as those with specific affinity to SARS-CoV-2 biomarkers, providing unprecedented flexibility in biomarker identification and diagnosis.

    A sampling system for easy use in clinical settings

    BreathBiomicsTM sampling system provides unparalleled versatility in its integration into a variety of respiratory devices including facial masks, mouthpieces, mechanical ventilators, oxygen masks, incubators, and tracheostomy tubes. Its quiet operation, with noise levels below 45 dB (comparable to the hum of a home refrigerator), makes it ideally suited for deployment in clinical settings, ranging from primary care sites to emergency rooms, operating rooms, and intensive care units.

    Collaborate with us

    Zeteo Tech is at the forefront of harnessing advanced technology to unlock the full potential of human breath as a diagnostic tool. With our innovative BreathBiomicsTM sampling system, we aim to revolutionize disease diagnosis by extracting invaluable biological information from human breath.

    We have partnered with top scientists and physicians to seek solutions for early and accurate diagnosis of lung diseases. We invite you to join us in exploring the limitless possibilities of human breath research and collaborate with us to develop ground-breaking diagnostic solutions.

    Dapeng Chen, PhD: dapeng.chen@zeteotech.com

    Michael McLoughlin: mike.mcloughlin@zeteotech.com

    Wayne Bryden, PhD: wayne.bryden@zeteotech.com

     

    Resources:

    • Zeteo Tech Awarded Competitive Grant From the National Institute of Allergy and Infectious Diseases – Zeteo Tech
    • Chen, Dapeng, et al. “Human exhaled air diagnostic markers for respiratory tract infections in subjects receiving mechanical ventilation.” Journal of Breath Research2 (2023): 026001.
    • Chen, Dapeng, et al. “MALDI-TOF Mass Spectrometric Detection of SARS-CoV-2 Using Cellulose Sulfate Ester Enrichment and Hot Acid Treatment.” Journal of Proteome Research8 (2022): 2055-2062.
    • Chen, Dapeng, et al. “Non-volatile organic compounds in exhaled breath particles correspond to active tuberculosis.” Scientific reports1 (2022): 1-11.
    • Chen, Dapeng, et al. “Capture of viruses and microorganisms in aerosols using a newly designed collection system: A proof-of-concept study.” bioRxiv (2021): 2021-06.
    • Chen, Dapeng, Wayne A. Bryden, and Michael McLoughlin. “A novel system for the comprehensive collection of nonvolatile molecules from human exhaled breath.” Journal of Breath Research 1 (2020): 016001.
    • Chen, Dapeng, Wayne A. Bryden, and Robin Wood. “Detection of tuberculosis by the analysis of exhaled breath particles with high-resolution mass spectrometry.” Scientific reports 1 (2020): 764